What question did this study set out to answer?

To evaluate the impact of chronic converting enzyme inhibition via captopril on blood pressure and daily sodium balance in conscious mice.

November 1, 1998Hypertension

Chronic Sodium Balance and Blood Pressure Response to Captopril in Conscious Mice

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Why the study?

Does intravenous captopril reduce blood pressure and alter sodium balance in conscious mice?

Population

Conscious Swiss Webster mice

Comparison

Intravenous captopril infusion for 5 days vs Baseline and post-control days

Design

Preclinical

Follow-up

5 days of infusion and 5 postcontrol days

Authors

DMDavid L. MattsonAugusta University KKKristyn R. KrauskiMedical College of Wisconsin

Discussion

Member takes

Implication

Natriuresis may contribute to ACE-inhibitor BP effects in mice; leaves open translation to human hypertension.

Key Points

To evaluate the impact of chronic converting enzyme inhibition via captopril on blood pressure and daily sodium balance in conscious mice.
Conscious Swiss Webster mice were implanted with chronic indwelling arterial catheters and maintained on continuous intravenous saline infusions alongside 24-hour daily urine collections.
Mice received intravenous captopril (40 mg·kg⁻¹·d⁻¹, n=7) at a fixed sodium intake (~200 µmol/d) for 5 days, following baseline validation across variable sodium intakes (160 to 1,000 µmol/d, n=20) and furosemide challenge (n=7).
Sodium balance validation confirmed a 100±3% recovery rate across a 5-fold intake range without alterations in baseline mean arterial pressure (115±7 mm Hg), heart rate (646±12 bpm), or body weight (34±0.6 g).
Captopril administration attenuated the pressor response to a 10-ng bolus of angiotensin I from 24±5 mm Hg to 6±2 mm Hg (n=5).
Five days of captopril infusion significantly decreased mean arterial pressure from 114±3 to 58±2 mm Hg, decreased body weight from 36±1 to 33±1 g, and produced a cumulative sodium deficit of -270±55 µmol (n=7), all of which reversed post-treatment.

Structured PICO

Does intravenous captopril reduce blood pressure and alter sodium balance in conscious mice?

Population

Conscious Swiss Webster mice (n=7 for captopril experiment, plus additional validation groups of n=20, n=7, and n=5)

Intervention

Intravenous captopril infusion (40 mg/kg/d) for 5 days

Comparator

Baseline (pre-infusion control state) and post-control days

Outcome

Mean arterial pressure and cumulative sodium balancesurrogate

Chronic ACE inhibition with captopril potently lowers blood pressure in normal conscious mice, partly driven by increased urinary sodium excretion.

Cite This Study

Mattson et al. (1998) studied this question.

synapsesocial.com/papers/6a8aefd0eee946ed63e3a72d https://doi.org/10.1161/01.hyp.32.5.923

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Chronic Sodium Balance and Blood Pressure Response to Captopril in Conscious Mice

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Chronic Sodium Balance and Blood Pressure Response to Captopril in Conscious Mice

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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