Why the study?
Does captopril lower blood pressure in genetically hypertensive, normotensive and hypotensive mice under normal and salt-loaded conditions?
Population
Inbred mice that were genetically hypertensive, normotensive or hypotensive
Comparison
Captopril in drinking water for 7 days, 0.85%… vs Water or saline controls
Design
Preclinical
Follow-up
up to 14 days
Authors
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Captopril efficacy across BP phenotypes persists with salt loading; leaves open translation to human hypertension management.
Does captopril lower blood pressure in genetically hypertensive, normotensive and hypotensive mice under normal and salt-loaded conditions?
Captopril effectively lowers systolic blood pressure in mice regardless of baseline blood pressure status, and its ultimate efficacy is maintained even with concurrent salt loading.
B Leckie (2001) studied this question.
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