Key result
A febrile patient with Brugada syndrome and COVID-19 infection developed an electrical storm, illustrating fever as a trigger for ventricular fibrillation.
Case Report (n=1)
Highlights fever associated with COVID-19 infection as a potential trigger for life-threatening ventricular arrhythmias in patients with Brugada syndrome.
Should not yet change Brugada management; extends potential triggers but remains hypothesis-generating.
The eponymous syndrome first described by the Brugada brothers in the early 1990s consists of characteristic ST abnormalities and an increased risk of sudden cardiac death due to ventricular arrhythmias.1 Since that time, further genetic research has implicated hundreds of variants in 17 genes with mutations in SCN5A, coding for voltage-gated sodium channels, accounting for the majority of genotyped patients.2 Various triggers have been associated with the development of ventricular fibrillation (VF) in this patient population, including fever and alcohol intake.
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Maglione et al. (2020) conducted a case report in Brugada syndrome and COVID-19 infection (n=1). COVID-19 infection and fever was evaluated on Electrical storm. A febrile patient with Brugada syndrome and COVID-19 infection developed an electrical storm, illustrating fever as a trigger for ventricular fibrillation.
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