Reproductive hormones (estrogen-progesterone) modulate AT1 receptor levels in the dorsomedial arcuate nucleus, which may mediate the inhibition of the prolactin surge.
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Reproductive hormone effects on AT1 receptors appear estrus-specific in rats; leaves open relevance to human neuroendocrine or cardiovascular regulation.
Angiotensin II AT1 receptors are highly localized in the dorsomedial arcuate nucleus. AT1 receptor number is very low during proestrus and in ovariectomized and male rats, and is high only during the estrus phase of the estrous cycle and after ovariectomized rats receive a sequential estrogen-progesterone treatment. Our results suggest that the mechanism of the estrogen-progesterone inhibition of the prolactin surge may involve the selective stimulation of dorsomedial arcuate AT1 receptors.
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Seltzer et al. (1993) studied this question.
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