Why the study?
Does a single oral dose of enalapril or lisinopril cause accumulation of angiotensin I in normal volunteers?
Does a single oral dose of enalapril or lisinopril cause accumulation of angiotensin I in normal volunteers?
The rise in angiotensin I after ACE inhibition is due to enhanced renin release rather than accumulation of angiotensin I.
ACE inhibition raises angiotensin I via renin release, not accumulation; hypothesis-generating in volunteers and should not yet change practice.
In nine normal volunteers, a series of five venous blood samples was obtained before and up to 24 h after converting enzyme inhibition by a single oral dose of enalapril or lisinopril. Plasma renin activity and blood angiotensin I were measured. A close linear relationship was found between the increase in plasma renin activity and the increase in blood angiotensin I. The linear correlation between plasma renin activity and blood angiotensin I remained after converting enzyme inhibition. Thus, the rise in angiotensin I after inhibition of the conversion of angiotensin I to angiotensin II is due to an enhanced release of renin rather than to accumulation of angiotensin I.
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Nussberger et al. (1987) studied this question.
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