Key result
Influenza infection (n=11) compared to non-influenza infection (n=11) in children with acute necrotizing encephalopathy showed no significant differences in clinical symptoms or outcomes.
Why the study?
Does influenza infection compared to non-influenza infection alter the clinical presentation and outcome in children with acute necrotizing encephalopathy?
Population
22 children with acute necrotizing encephalopathy (ANE)
Comparison
Influenza infection (n=11) vs Non-influenza infection (n=11)
Design
Cohort
Authors
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Supports uniform management regardless of trigger in pediatric acute necrotizing encephalopathy; leaves open pathogen-specific mechanisms in larger cohorts.
Observational (n=22)
Does influenza infection compared to non-influenza infection alter the clinical presentation and outcome in children with acute necrotizing encephalopathy?
The pathogenesis and clinical course of acute necrotizing encephalopathy in children do not appear to depend on whether the triggering infectious agent is influenza.
Okumura et al. (2009) conducted an observational in Acute necrotizing encephalopathy (n=22). Influenza infection vs. Non-influenza infection was evaluated on Clinical symptoms, laboratory and neuroimaging findings, and outcome. Influenza infection (n=11) compared to non-influenza infection (n=11) in children with acute necrotizing encephalopathy showed no significant differences in clinical symptoms or outcomes.
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