Key result
Heart transplant recipients had a steeper ventilatory response to exercise than matched referents (38 vs 29 L/mm Hg; P<0.01), which was related to increased peripheral chemoreceptor sensitivity.
Why the study?
Are peripheral chemoreceptor sensitivity and exercise ventilation increased in heart transplant recipients compared to matched referent subjects?
Population
19 heart transplant recipients with normal left ventricular ejection fraction 7+/-1 years after…
Comparison
Isocapnic hypoxia, hyperoxic hypercapnia, and… vs Closely matched referent subjects
Design
Cross-sectional
Authors
Loading...
May underlie persistent exercise hyperpnea post-transplant; hypothesis-generating and requires prospective validation before clinical consideration.
Observational (n=30)
Are peripheral chemoreceptor sensitivity and exercise ventilation increased in heart transplant recipients compared to matched referent subjects?
Absolute Event Rate: 38% vs 29%
p-value: p=<0.01
Peripheral chemoreceptor sensitivity remains increased in heart transplant recipients and is linked to exercise hyperpnea, providing a physiological mechanism for persistent abnormal ventilatory responses post-transplantation.
Ciarka et al. (2006) conducted an observational in Heart transplantation (n=30). Heart transplantation vs. Matched referent subjects was evaluated on Ventilatory response to exercise (regression slope relating minute ventilation to CO2 output) (p=<0.01). Heart transplant recipients had a steeper ventilatory response to exercise than matched referents (38 vs 29 L/mm Hg; P<0.01), which was related to increased peripheral chemoreceptor sensitivity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: