July 1, 1980Circulation
Cardiorespiratory responses of cardiac transplant patients to graded, symptom-limited exercise.
Why the study?
Does graded, symptom-limited exercise elicit different cardiorespiratory responses in cardiac transplant patients compared to normal men?
Population
15 denervated heart patients who had undergone cardiac transplantation and 14 age-matched, normally…
Comparison
Graded, symptom-limited treadmill exercise vs Age-matched, normally innervated men undergoing…
Design
Cross-sectional
Authors
Discussion
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Implication
Warrants caution in exercise prescription for transplant recipients; leaves open mechanisms of impaired capacity for targeted study.
Key Points
- To compare the electrocardiographic and ventilatory responses to graded treadmill exercise between cardiac transplant recipients with denervated hearts and age-matched healthy controls.
- Evaluated 15 cardiac transplant patients with denervated hearts and 14 age-matched, normally innervated men during graded, symptom-limited treadmill exercise.
- Monitored continuous electrocardiographic variables, ventilatory parameters, and total work time, alongside a 5-minute postexercise venous lactate assessment.
- Healthy controls achieved significantly higher peak values than transplant recipients for heart rate (172 vs 159 beats/min), blood pressure (189 vs 167 mm Hg), oxygen uptake (37 vs 25 ml/kg/min), oxygen pulse (0.22 vs 0.16 ml/kg/beat), and work time (26.2 vs 18.0 minutes).
- Transplant recipients showed higher submaximal ventilation, higher submaximal respiratory exchange ratio, higher peak ventilatory equivalent (3.13 vs 2.14 l/ml/kg), and higher postexercise venous lactate levels, without significant differences in peak ventilation or peak respiratory exchange ratio.
- Work time among cardiac transplant recipients correlated inversely with their clinical rejection history (r = -0.59, p < 0.01).
Structured PICO
Does graded, symptom-limited exercise elicit different cardiorespiratory responses in cardiac transplant patients compared to normal men?
P
Population
15 denervated heart patients who had undergone cardiac transplantation and 14 age-matched, normally innervated men (total n=29).
I
Intervention
Graded, symptom-limited treadmill exercise
C
Comparator
Age-matched, normally innervated men undergoing the same exercise protocol
O
Outcome
Electrocardiographic and ventilatory responses to graded treadmill exercise (including heart rate, blood pressure, oxygen uptake, oxygen pulse, work time, peak ventilatory equivalent, and lactate)surrogate
Cardiac transplant recipients exhibit diminished exercise capacity and altered cardiorespiratory responses compared to normal individuals, reflecting an impaired ability to meet peripheral oxygen demands.
Cite This Study
Savin et al. (1980) studied this question.