July 1, 1959Journal of Applied Physiology

Viscous metamorphosis, clot retraction and other morphologic alterations of blood platelets

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Population

Washed blood platelets (in vitro model)

Design

Preclinical

Authors

MZMarjorie B. ZuckerUniversity of North Carolina at Chapel Hill JBJennie BorrelliKettering University

Discussion

Member takes

Implication

These pH- and calcium-dependent platelet effects remain hypothesis-generating in animal models; human studies needed before clinical translation.

Structured PICO

Population

Washed blood platelets (in vitro model)

Intervention

Various chemical and environmental conditions including thrombin, pH alterations, diisopropylfluorophosphate (DFP), heparin, calcium binding anticoagulants, cyanide, fluoride, and mercuric chloride

Outcome

Viscous metamorphosis (VM) and clot retractionsurrogate

This early basic science study characterizes the biochemical and environmental dependencies of platelet viscous metamorphosis and clot retraction, highlighting the roles of thrombin, pH, calcium, and various inhibitors.

Cite This Study

Zucker et al. (1959) studied this question.

synapsesocial.com/papers/6a8b8e1bc716e89f35dee828 https://doi.org/10.1152/jappl.1959.14.4.575

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Implication

These pH- and calcium-dependent platelet effects remain hypothesis-generating in animal models; human studies needed before clinical translation.

Viscous metamorphosis, clot retraction and other morphologic alterations of blood platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Viscous metamorphosis, clot retraction and other morphologic alterations of blood platelets

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider