Why the study?
Does metoprolol 300 mg once daily versus three times daily reduce blood pressure and provide steady beta-blockade in hypertensive patients?
Population
16 hypertensive patients
Comparison
Metoprolol 300 mg in a single daily dose vs Metoprolol 300 mg/day in three doses and placebo
Design
RCT, random order, double-blind
Authors
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Once-daily metoprolol suffices for BP lowering in hypertension; extends dosing flexibility evidence while cautioning on fluctuations if steady beta-blockade is required.
Does metoprolol 300 mg once daily versus three times daily reduce blood pressure and provide steady beta-blockade in hypertensive patients?
A single 300 mg daily dose of metoprolol is sufficient for blood pressure reduction, but a thrice-daily regimen is required if a steady degree of beta-blockade is needed.
Reybrouck et al. (1978) studied this question.
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