Why the study?
Does prindolol improve treatment response in patients with varying grades of hypertension?
Does prindolol improve treatment response in patients with varying grades of hypertension?
Prindolol is a useful agent in the management of mild to complicated hypertension when used alone.
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Prindolol supports monotherapy across hypertension grades; confirms RCT benefit and extends evidence to complicated cases.
The mechanism of action of the beta-adrenergic blocking agents in the management of hypertension has not been fully elucidated. Of a group of 20 patients with varying grades of hypertension treated with prindolol, 18 appeared to respond well, and two not at all. Fourteen of the original group of 20 were submitted to a double-blind trial. Results were significant in favour of the active agent, and indicate that prindolol is a useful agent in the management of mild to complicated hypertension when used alone.
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Peter Thorpe (1972) studied this question.
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