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July 6, 2025Thrombosis ResearchOpen Access

“Who am I to say that I'm not going to take it”: patient perspectives on decisions about antithrombotic therapy in the context of advanced cancer

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Why the study?

Reconsidering antithrombotic therapy in cancer patients nearing the end of life is complex, and patient experiences, values, and perspectives remain largely unexplored.

Design

Qualitative study using semi-structured interviews and Framework Analysis

Authors

EBElin BaddeleyCFCarme FontIMIsabelle Mahé

Discussion

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Overview

Patient perspectives on ATT near end-of-life inform DST development; leaves open need for prospective validation before practice change.

Structured PICO

P
Population
60 patients with advanced cancer receiving antithrombotic therapy (ATT), and 13 relatives
I
Intervention
Decision-making regarding antithrombotic therapy (ATT) use and deprescription
O
Outcome
Patients' experiences, values, and perspectives regarding ATT usepatient reported

Patients with advanced cancer are hesitant to discontinue antithrombotic therapy but trust clinicians to lead decision-making, highlighting the need for shared decision-making tools.

Cite This Study

Baddeley et al. (2025) studied this question.

synapsesocial.com/papers/6a8bafdf0ca85c7e33df015ahttps://doi.org/10.1016/j.thromres.2025.109399
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinician perspectives on antithrombotic therapy management in advanced cancer: a multinational qualitative study2026
  2. 2Understanding European patterns of deprescribing antithrombotic medication during end-of-life care in patients with cancer2024 · 10 citations
  3. 3Shared decision-making and deprescribing to support anti-thrombotic therapy (dis)continuance for persons living with cancer in their last phase of life: A realist synthesis2025
  4. 4Anti‐thrombotic therapy in patients with cancer at the end of life and associated clinical outcomes: A cohort study using population‐linked routinely collected data2025
  5. 5Use of antithrombotic therapy and the risk of cardiovascular outcomes and bleeding in cancer patients at the end of life: a Danish nationwide cohort study2024 · 14 citations