Why the study?
Does an aliskiren/amlodipine combination improve ambulatory blood pressure and target organ protection compared to high-dose amlodipine monotherapy in elderly essential hypertensive patients?
Population
105 elderly essential hypertensive patients with clinic BP ≥140/90 mm Hg while on amlodipine 5 mg
Comparison
Aliskiren and amlodipine combination therapy for… vs High-dose amlodipine monotherapy for 16 weeks
Design
RCT, randomly allocated, open-label
Follow-up
16 weeks
Authors
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Caution against aliskiren/amlodipine for morning BP surge; challenges combination superiority over high-dose amlodipine in elderly hypertension.
Does an aliskiren/amlodipine combination improve ambulatory blood pressure and target organ protection compared to high-dose amlodipine monotherapy in elderly essential hypertensive patients?
In elderly hypertensive patients, aliskiren/amlodipine combination therapy provides greater reduction in albuminuria but is less effective at controlling early-morning blood pressure surge compared to high-dose amlodipine.
Mizuno et al. (2015) studied this question.
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