Why the study?
Does intravenous R-PEP-27 reduce blood pressure and plasma angiotensin II in normal human subjects?
Population
6 normal human subjects on low and high sodium intake diets
Comparison
Intravenous infusion of R-PEP-27 vs Baseline and high sodium intake diet state
Design
Other
Follow-up
at the end of the infusion
Authors
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Acute BP reduction with low-sodium diet seen in normals; leaves open adjunctive role for R-PEP-27 in hypertension.
Does intravenous R-PEP-27 reduce blood pressure and plasma angiotensin II in normal human subjects?
R-PEP-27 is a potent, short-acting renin inhibitor that effectively reduces blood pressure and angiotensin II levels in normal subjects on a low sodium diet.
Zusman et al. (1994) studied this question.
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