Why the study?
Does H142 infusion reduce plasma active renin concentration and blood pressure in male volunteers?
Population
9 male volunteers
Comparison
H142 infused at 1.0 or 2.5 mg/kg per h for 30… vs 5% dextrose infusion
Design
RCT, in random order
Follow-up
2 hours
Authors
Loading...
Supports renin inhibition for BP lowering; confirms in vivo human efficacy and warrants further development.
Does H142 infusion reduce plasma active renin concentration and blood pressure in male volunteers?
H142 effectively inhibits human renin in vivo, leading to reductions in angiotensin I and II and a dose-related fall in diastolic blood pressure.
Webb et al. (1985) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: