November 12, 1999Circulation Research
A Subpopulation of Cardiomyocytes Expressing α-Skeletal Actin Is Identified by a Specific Polyclonal Antibody
Population
Newborn and adult rats
Comparison
Immunostaining using a newly developed specific… vs Normal myocardium vs. hypertrophic myocardium
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating in rat hypertrophy models; leaves open translational role in human cardiac remodeling.
Structured PICO
P
Population
Newborn and adult rats (normal or hypertensive with or without fibrotic areas induced by aortic ligature between the renal arteries)
I
Intervention
Immunostaining using a newly developed specific polyclonal antibody against the NH(2)-terminal decapeptide of alpha-skeletal actin
C
Comparator
Normal myocardium vs. hypertrophic myocardium
O
Outcome
Distribution and expression of alpha-skeletal actin in the myocardiumsurrogate
A newly developed specific antibody reveals that alpha-skeletal actin expression is restricted in normal adult rat hearts but increases focally during cardiac hypertrophy, providing insight into cardiac adaptation to work overload.
Cite This Study
Clément et al. (1999) studied this question.