Population
Cultured myotubes and adult skeletal myofibrils (myogenic cells and adult skeletal muscle)
Design
Preclinical
Authors
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Highlights isoform-specific actin roles in myotube maturation; extends cell biology insights but leaves open relevance to mammalian cardiac muscle.
The study demonstrates a heterogeneous distribution of muscle and nonmuscle actin isoforms in differentiating myogenic cells and shows that nonmuscle actin is a component of the muscle contractile apparatus.
Otey et al. (1988) studied this question.
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