Key result
Alpha-sarcomeric actins are assembled preferentially into striated myofibrils in developing muscle cells compared to cytoskeletal actins, although both can be incorporated.
This in vitro study demonstrates that while both cytoskeletal and sarcomeric actins can incorporate into myofibrils, sarcomeric alpha-actins are preferentially assembled during muscle cell development.
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Caution against clinical extrapolation from this animal study; extends knowledge of actin assembly but remains hypothesis-generating.
Hayakawa et al. (1996) studied Developing skeletal muscle cells in vitro. Microinjection of FITC-labeled cytoskeletal and sarcomeric actins was evaluated on Subcellular localization and assembly of actin isoforms. Alpha-sarcomeric actins are assembled preferentially into striated myofibrils in developing muscle cells compared to cytoskeletal actins, although both can be incorporated.
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