Why the study?
Does lignocaine alter the ventricular fibrillation threshold and vulnerable period in isolated perfused rat hearts?
Does lignocaine alter the ventricular fibrillation threshold and vulnerable period in isolated perfused rat hearts?
Lignocaine elevates the ventricular fibrillation threshold and delays the vulnerable period to the end of the QT interval in isolated rat hearts.
Lignocaine may raise VF threshold in rat hearts; leaves open translation to in vivo or clinical arrhythmia prevention.
Ventricular fibrillation threshold (VFT) measurements were obtained in the isolated perfused rat heart. Detailed morphology of the vulnerable period (VP) could be described by stimulating repeatedly at increasing levels of stimulus energy. Addition of lignocaine to the system caused an elevation of VGT, but also led to a delay of the VP to the end of the QT interval. The implications of these findings for the understanding of VFT measurements are discussed.
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Lubbe et al. (1975) studied this question.
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