Why the study?
Do antidysrhythmic drugs with membrane-stabilizing properties increase the ventricular fibrillation threshold in spontaneously hypertensive rats?
Do antidysrhythmic drugs with membrane-stabilizing properties increase the ventricular fibrillation threshold in spontaneously hypertensive rats?
Spontaneously hypertensive rats have a lower ventricular fibrillation threshold than normotensive rats, and this threshold is increased by membrane-stabilizing antidysrhythmic drugs, suggesting SHR is a useful model for screening such compounds.
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Hypothesis-generating for membrane-stabilizing agents in hypertensive arrhythmia; leaves open translation to human risk.
Versailles et al. (1982) studied this question.
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