Why the study?
Does myocardial stretch and increased ventricular mass influence the ventricular fibrillation threshold in the absence of ischemia in isolated rat hearts?
Does myocardial stretch and increased ventricular mass influence the ventricular fibrillation threshold in the absence of ischemia in isolated rat hearts?
Myocardial stretch and increased ventricular mass independently lower the ventricular fibrillation threshold in the absence of ischemia, which may explain the increased risk of lethal arrhythmias in dilated cardiomyopathy.
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Supports stretch as proarrhythmic factor without ischemia; leaves open translation to human dilated cardiomyopathy.
Rosen et al. (1991) studied this question.
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