Key result
Ventricular weight fails to alter fibrillation threshold but spontaneous defibrillation ceases above 12 grams.
Why the study?
Does ventricular weight affect fibrillation threshold and spontaneous defibrillation in a canine model?
Population
50 mongrel dogs of both sexes, including 26 puppies and 24 adult animals of undetermined age
Design
Preclinical
Authors
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Should not inform clinical VF management by heart size; leaves open translational validation of spontaneous defibrillation thresholds in larger mammals.
Does ventricular weight affect fibrillation threshold and spontaneous defibrillation in a canine model?
Effect estimate: Correlation < 0.4
Ventricular weight does not affect the electrical threshold required to induce fibrillation, but it dramatically reduces the myocardium's capacity to spontaneously revert the arrhythmia.
Ruiz et al. (1994) studied Ventricular fibrillation (n=50). Ventricular weight was evaluated on Fibrillation threshold and spontaneous defibrillation (Correlation < 0.4). Ventricular weight did not affect fibrillation threshold (correlation < 0.4), but spontaneous defibrillation was essentially nonexistent for heart weights higher than 12 grams.
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