Why the study?
Does right atrial stretch induce renal nerve inhibition and c-fos expression in the paraventricular nucleus in rats?
Population
Anaesthetised rats
Comparison
Selective stimulation of right atrial receptors… vs Normotensive control group
Design
Preclinical
Follow-up
1 hour
Authors
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Hypothesis-generating for atrial stretch reflexes; leaves open translation to human sympathetic regulation in HF or hypertension.
Does right atrial stretch induce renal nerve inhibition and c-fos expression in the paraventricular nucleus in rats?
Selective right atrial stretch in rats inhibits renal sympathetic nerve activity and induces c-fos expression specifically in parvocellular neurones of the paraventricular nucleus.
Pyner et al. (2002) studied this question.
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