July 1, 2000Civil War Book Review
Lack of association of the angiotensinogen-6 polymorphism with blood pressure levels in the comprehensive NHLBI Family Blood Pressure Program
Why the study?
Is the angiotensinogen-6 polymorphism (AGT-6) associated with blood pressure levels in a diverse population?
Population
4,322 subjects from the NHLBI Family Blood Pressure Program across four networks, including Caucasian…
Design
Cohort
Authors
Discussion
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Member takes
Implication
AGT-6 shows no significant BP association in diverse cohorts; leaves open roles for other genetic variants in hypertension.
Structured PICO
Is the angiotensinogen-6 polymorphism (AGT-6) associated with blood pressure levels in a diverse population?
P
Population
4,322 subjects from the NHLBI Family Blood Pressure Program (FBPP) across four networks (GenNet, GENOA, HyperGEN, SAPPHIRe), including Caucasian, African-American, Japanese, and Chinese ethnic groups.
I
Intervention
Angiotensinogen-6 polymorphism (AGT-6)
O
Outcome
Blood pressure levels (systolic and diastolic)surrogate
The angiotensinogen-6 polymorphism has minimal to no effect on inter-individual variation in blood pressure levels in the general population.
Cite This Study
Province et al. (2000) studied this question.