Population
Nonbinephrectomized and binephrectomized spontaneously hypertensive rats (SHRs)
Design
Preclinical
Follow-up
8 days
Authors
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Findings limited to animal models; leaves open clinical translation of perindopril's renal and sympathoinhibitory effects.
Perindopril lowers blood pressure in spontaneously hypertensive rats through a renal-dependent mechanism and exerts sympathoinhibitory effects.
Richer et al. (1986) studied this question.
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