Population
Rabbits immunized with ouabain conjugate and canine myocardial microsomal Na+, K+-activated ATPase
Design
Preclinical
Follow-up
45 weeks (immunization period)
Authors
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May inform experimental antidotes for glycoside toxicity; leaves open human translation from canine models.
Ouabain-specific antibodies possess high affinity and specificity, allowing for precise radioimmunoassay measurements and the reversal of cellular effects of ouabain toxicity.
Thomas W. Smith (1972) studied this question.
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