Why the study?
What is the frequency of the C1166 variant of the angiotensin II type I receptor in African Americans compared to Caucasians?
What is the frequency of the C1166 variant of the angiotensin II type I receptor in African Americans compared to Caucasians?
The C1166 variant of the AT1 receptor, previously associated with hypertension in Caucasians, is significantly less frequent in African Americans.
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May limit applicability of C1166 hypertension associations to African Americans; leaves open ancestry-specific validation.
Gainer et al. (1997) studied this question.
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