Enzymatic creatinine assays demonstrate superior performance compared to Jaffé methods when evaluated against an HPLC reference, highlighting the need for caution in survey performance criteria.
Supports enzymatic creatinine assays for labs; leaves open refinement of survey performance criteria.
We analysed the results of surveys on creatinine held in The Netherlands during the years 1992, 1993 and 1994. Assay results of 113 samples were reviewed: 88 human sera and 25 samples of animal origin. The results of 5 creatinine assays, 4 based on the Jaffé reaction and 1 enzymatic procedure, are discussed. The enzymatic assay showed by far the best performance, while some of the Jaffé methods differed considerably. All results were evaluated by reference to a HPLC-based selected method for creatinine. Our study shows the need for caution when applying survey performance criteria for creatinine.
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Blijenberg et al. (1995) studied this question.
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