April 1, 2003Hypertension

Differential Expression of AT 1 Receptors in the Pituitary and Adrenal Gland of SHR and WKY

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Structured PICO

Population

Male spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats (WKY) at prehypertensive (3 to 4 weeks), developing (7 to 8 weeks), and established (12 to 13 weeks) stages of hypertension.

Intervention

Measurement of mRNA expression of AT1A, AT1B, and AT2 receptors; ANG administration in dexamethasone-treated rats

Comparator

Normotensive Wistar-Kyoto rats (WKY)

Outcome

mRNA expression of AT1A, AT1B, and AT2 receptors in the hypothalamo-pituitary-adrenal axissurrogate

Differential gene expression of AT1A and AT1B receptors in the HPA axis of SHR suggests AT1 receptors participate in an exaggerated endocrine stress response to angiotensin in hypertension.

Discussion

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Implication

Does not alter hypertension management; leaves open pituitary AT1 receptor subtypes in human HPA dysregulation.

Cite This Study

Jöhren et al. (2003) studied this question.

synapsesocial.com/papers/6a8be41d60c8c47a9ee3f120 https://doi.org/10.1161/01.hyp.0000062466.38314.b7

Topics

Hypertension management

View Full Paper

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Differential Expression of AT 1 Receptors in the Pituitary and Adrenal Gland of SHR and WKY

Structured PICO

Discussion

Implication

Cite This Study

Topics

Differential Expression of AT 1 Receptors in the Pituitary and Adrenal Gland of SHR and WKY

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider