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December 2, 1994European Heart Journal

Cloning, Expression and Regulation of Angiotensin II Receptors

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Population

Bovine adrenal, rat vascular smooth muscles, human cells, and rat pheochromocytoma cells

Design

Preclinical

Authors

TITadashi InagamiNIN. IwaiKSKeisuke Sasaki

Discussion

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Overview

Defines receptor signaling in recombinant systems; leaves open translation to cardiovascular disease models or therapies.

Structured PICO

P
Population
Bovine adrenal, rat vascular smooth muscles, human cells, and rat pheochromocytoma cells
I
Intervention
Cloning and expression of Angiotensin II receptors (AT1 and AT2)
O
Outcome
Receptor structure and signaling mechanisms

The cloning of AT1 and AT2 receptors reveals they are seven transmembrane domain receptors with distinct signaling mechanisms, including AT2's unique pertussis toxin-sensitive inhibition of phosphotyrosine phosphatase.

Cite This Study

Inagami et al. (1994) studied this question.

synapsesocial.com/papers/6a8be42e71fd1aba2c8b9568https://doi.org/10.1093/eurheartj/15.suppl_d.104
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of two subtypes in the rat type I angiotensin II receptor1992 · 401 citations
  2. 2Molecular Insights Into Angiotensin II Receptor Subtypes1993 · 16 citations
  3. 3Cloning, expression and regulation of angiotensin II receptors1992 · 60 citations