September 1, 1996The Journal of PhysiologyOpen Access

Potentiation of IPSCs by nitric oxide in immature rat sympathetic preganglionic neurones in vitro.

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Population

Transverse thoracolumbar spinal cord slices from 8- to 12-day-old rats containing sympathetic preganglionic…

Comparison

Superfusion with NO precursor L-arginine and NO… vs Pretreatment with bovine haemoglobin, NO-Arg, or…

Design

Preclinical

Authors

SWSu‐Ying WuShandong University of Traditional Chinese Medicine NDNae J. DunNew Mexico State University

Discussion

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Implication

May indicate NO retrograde signaling in sympathetic neurons; leaves open relevance to human cardiovascular autonomic control.

Structured PICO

Population

Transverse thoracolumbar spinal cord slices from 8- to 12-day-old rats containing sympathetic preganglionic neurones (SPNs)

Intervention

Superfusion with NO precursor L-arginine (300 microM) and NO donor sodium nitroprusside (100 microM), or dbcGMP (300 microM) with IBMX (750 microM)

Comparator

Pretreatment with bovine haemoglobin (100 microM), NO-Arg (100 microM), or ODQ (1 microM)

Outcome

Inhibitory postsynaptic current (IPSC) amplitude and potentiationsurrogate

Nitric oxide released endogenously from sympathetic preganglionic neurones may act as a retrograde messenger to enhance inhibitory transmitter release via a cGMP-dependent mechanism.

Cite This Study

Wu et al. (1996) studied this question.

synapsesocial.com/papers/6a8beecae066a6a97ec45f1f https://doi.org/10.1113/jphysiol.1996.sp021608

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Potentiation of IPSCs by nitric oxide in immature rat sympathetic preganglionic neurones in vitro.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Potentiation of IPSCs by nitric oxide in immature rat sympathetic preganglionic neurones in vitro.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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