Structural alterations in resistance arteries of spontaneously hypertensive rats are prevented by enalapril treatment, whereas intrinsic alterations in arterial muscle contractility persist, suggesting contractility changes are primary to high blood pressure.
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ACE inhibition may normalize resistance artery structure without restoring muscle contractility in SHR; leaves open whether contractility defects primarily drive hypertension.
C. S. Packer (1994) studied this question.
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