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November 10, 2005AJP Cell Physiology

The depressive effect of Pi on the force-pCa relationship in skinned single muscle fibers is temperature dependent

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Population

Chemically skinned single muscle fibers isolated from rat soleus (slow) and gastrocnemius (fast) muscle

Comparison

30 mM inorganic phosphate at low and high… vs Absence of 30 mM Pi at corresponding temperatures

Design

Preclinical

Authors

EDEdward P. DeboldHeart Failure / CardiomyopathyJRJ. G. RomatowskiMarquette UniversityRFR. H. FittsMarquette University

Discussion

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Implication

May inform fatigue mechanisms at physiological temperatures; extends animal data on Pi-Ca2+ synergy but leaves human translation open.

Structured PICO

P
Population
Chemically skinned single muscle fibers isolated from rat soleus (slow) and gastrocnemius (fast) muscle
I
Intervention
30 mM inorganic phosphate (Pi) at low (15 degrees C) and high (30 degrees C) temperatures
C
Comparator
Absence of 30 mM Pi at corresponding temperatures
O
Outcome
Force-Ca(2+) relationship (activation threshold and Ca(2+) required to elicit half-maximal force [pCa50])surrogate

Reductions in myoplasmic Ca2+ and increases in Pi act synergistically to reduce muscular force during fatigue, with a more pronounced effect at near-physiological temperatures.

Cite This Study

Debold et al. (2005) studied this question.

synapsesocial.com/papers/6a8c182e98aeeda2ff8932cehttps://doi.org/10.1152/ajpcell.00342.2005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Temperature dependence of active tension in mammalian (rabbit psoas) muscle fibres: effect of inorganic phosphate2001 · 127 citations
  2. 2Reduced effect of pH on skinned rabbit psoas muscle mechanics at high temperatures: implications for fatigue.1995 · 197 citations
  3. 3It Is Diprotonated Inorganic Phosphate That Depresses Force in Skinned Skeletal Muscle Fibers1987 · 204 citations
  4. 4The role of troponin C in modulating the Ca2+ sensitivity of mammalian skinned cardiac and skeletal muscle fibres.1994 · 92 citations
  5. 5The relation between force and intracellular pH in fatigued, single Xenopus muscle fibres1988 · 67 citations