Population
Chemically skinned muscle fibers, prepared from the rat medial gastrocnemius and soleus
Comparison
Ca-activating solutions containing 15 and 30 mM… vs Ca-activating solutions containing 0 mM added P
Design
Preclinical
Authors
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Challenges cross-bridge models in slow-twitch fibers; hypothesis-generating for Pi effects in human muscle, with no clinical implications yet.
High concentrations of inorganic phosphate reduce unloaded shortening velocity in slow (type I) but not fast (type IIb) mammalian muscle fibers, challenging current cross-bridge models.
Jeffrey J. Widrick (2002) studied this question.
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