January 22, 1981Quarterly Journal of Experimental PhysiologyOpen Access

The Nature of Atrial Receptors Responsible for the Increase in Urine Flow Caused by Distension of the Left Atrium in the Dog

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Population

Dogs anaesthetized with alpha-chloralose

Comparison

Distension of a large balloon in the lumen of… vs Distension of the balloon with cervical vagi at…

Design

Preclinical

Authors

NSN SivananthanUniversity of Toronto CKC. T. KappagodaUniversity of California, Davis RLR. J. LindenLeeds General Infirmary

Discussion

Member takes

Implication

Animal vagal cooling data implicate myelinated atrial receptors in diuresis; leaves open human translation and clinical relevance.

Structured PICO

Population

Dogs anaesthetized with alpha-chloralose

Intervention

Distension of a large balloon in the lumen of the left atrium with cervical vagi cooled at 18 and 12 degrees C

Comparator

Distension of the balloon with cervical vagi at 37 degrees C

Outcome

Urine flow and discharge of action potentials in vagal fibressurrogate

The study demonstrates that the increase in urine flow caused by left atrial distension is mediated solely by Paintal-type atrial receptors discharging into myelinated vagal fibres.

Cite This Study

Sivananthan et al. (1981) studied this question.

synapsesocial.com/papers/6a8c1918f71b672e3df4b364 https://doi.org/10.1113/expphysiol.1981.sp002528

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The Nature of Atrial Receptors Responsible for the Increase in Urine Flow Caused by Distension of the Left Atrium in the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Nature of Atrial Receptors Responsible for the Increase in Urine Flow Caused by Distension of the Left Atrium in the Dog

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider