Hemostatic and Fibrinolytic Activation Is Less Following Cutting Balloon Angioplasty of the Coronary Arteries
Why the study?
Does cutting balloon angioplasty reduce systemic hemostatic and fibrinolytic activation compared to plain balloon angioplasty or stenting in patients with stable angina pectoris?
Population
61 patients with stable angina pectoris undergoing elective percutaneous coronary intervention or diagnostic…
Comparison
Cutting balloon (CB) angioplasty (n=11) vs Plain old balloon angioplasty, coronary…
Design
Cohort
Follow-up
3 days
Authors
Discussion
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Member takes
Implication
CB angioplasty may limit post-PCI hemostatic activation in stable angina; observational data leave clinical outcome effects open.
Structured PICO
Does cutting balloon angioplasty reduce systemic hemostatic and fibrinolytic activation compared to plain balloon angioplasty or stenting in patients with stable angina pectoris?
P
Population
61 patients with stable angina pectoris undergoing elective percutaneous coronary intervention (PCI) or diagnostic coronary angiography (CAG) alone.
I
Intervention
Cutting balloon (CB) angioplasty (n=11)
C
Comparator
Plain old balloon angioplasty (POBA) (n=11), coronary stenting (STENT) (n=27), or diagnostic coronary angiography (CAG) alone (n=12)
O
Outcome
Plasma concentrations of prothrombin fragment 1+2 (F1+2), fibrinopeptide A (FPA), thrombin-antithrombin III complex (TAT), and plasminogen activator inhibitor-1 (PAI-1) measured before, 24 hours after, and 3 days after the proceduresurrogate
Cutting balloon angioplasty induces significantly less systemic hemostatic and fibrinolytic activation compared to plain balloon angioplasty and stenting, which may contribute to favorable long-term outcomes.
Cite This Study
Namiki et al. (2004) studied this question.