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January 1, 2001Transfusion Medicine and Hemotherapy

Flow-Cytometric Analysis Comparing Platelet Activation during Percutaneous Transluminal Coronary Angioplasty, Stent Placement and Rotablation

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Why the study?

Do PTCA, stenting, and rotablation induce different patterns of platelet activation in patients undergoing coronary interventions?

Population

30 patients undergoing interventional cardiology procedures (PTCA n=12, stenting n=8, rotablation n=10)

Comparison

Percutaneous transluminal coronary angioplasty… vs Baseline and comparison between the three…

Design

Cohort

Follow-up

30 minutes after procedure

Authors

JBJ. BauUniversität HamburgCBC. BeythienEppendorf (Germany)MBMarc‐Alexander BrockmannUniversity of Applied Sciences Mainz

Discussion

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Implication

Temporal platelet activation patterns differ by procedure; hypothesis-generating for thrombotic risk stratification but should not yet change practice.

Structured PICO

Do PTCA, stenting, and rotablation induce different patterns of platelet activation in patients undergoing coronary interventions?

P
Population
30 patients undergoing interventional cardiology procedures (PTCA n=12, stenting n=8, rotablation n=10)
I
Intervention
Percutaneous transluminal coronary angioplasty (PTCA), stenting, or rotablation
C
Comparator
Baseline (before procedure) and comparison between the three techniques
O
Outcome
Platelet activation indicated by alterations in platelet antigens (CD41a, CD42b, CD62p, CD63, and fibrinogen binding) measured by flow cytometry directly after and 30 min after the proceduresurrogate

PTCA, stenting, and rotablation all induce significant platelet activation, but the temporal activation pattern differs between procedures, which may help identify patients at risk for thrombotic complications.

Cite This Study

Bau et al. (2001) studied this question.

synapsesocial.com/papers/6a92a756ab121d91d03ab9d7https://doi.org/10.1159/000050226
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of activation-dependent platelet membrane glycoproteins in development of subacute occlusive coronary stent thrombosis1997 · 43 citations
  2. 2A Comparison of Balloon-Expandable-Stent Implantation with Balloon Angioplasty in Patients with Coronary Artery Disease1994 · 4,563 citations
  3. 3Flow cytometric detection of platelet activation in patients undergoing diagnostic and interventional coronary angiography1996 · 10 citations
  4. 4Activation of Platelets in Platelet-Rich Plasma by Rotablation Is Speed-Dependent and Can Be Inhibited by Abciximab (c7E3 Fab; ReoPro)1998 · 104 citations
  5. 5Platelet Receptors for Collagens1995 · 34 citations