Key result
Percutaneous transluminal coronary angioplasty led to a significant loss of >50% of degranulated, activated platelets during the procedure, followed by a uniform increase post-procedure.
Why the study?
Does PTCA induce periprocedural changes in platelet activation in patients undergoing elective PTCA?
Population
25 consecutive patients admitted for elective percutaneous transluminal coronary angioplasty, preclassified…
Design
Cohort
Follow-up
2 hours after PTCA
Authors
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May link PTCA platelet consumption and rebound to ischemic risk; hypothesis-generating for periprocedural antiplatelet optimization.
Observational (n=25)
Does PTCA induce periprocedural changes in platelet activation in patients undergoing elective PTCA?
PTCA induces consumption of preactivated platelets and sustained platelet activation post-procedure, which may contribute to periprocedural ischemic events.
Kolarov et al. (1996) conducted an observational in Elective PTCA (n=25). Percutaneous transluminal coronary angioplasty (PTCA) vs. Baseline (before PTCA) was evaluated on Periprocedural changes in platelet activation and peripheral platelet count. Percutaneous transluminal coronary angioplasty led to a significant loss of >50% of degranulated, activated platelets during the procedure, followed by a uniform increase post-procedure.
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