Anticoagulant Related Nephropathy Only Partially Develops in C57BL/6 Mice: Hematuria Is Not Accompanied by Red Blood Cell Casts in the Kidney

Figures

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  Figure 1. Anticoagulation effects and mortality of warfarin and dabigatran treatments in 5/6 nephrectomy mice. (A,B) Changes in prothrombin time calculated as sINR in 5/6 nephrectomy mice treated with 2.5 mg/kg/day (n = 8) and 5.0 mg/kg/day (n = 8) of warfarin (A) or with 200 mg/kg/day (n = 7) and 400 mg/kg/day (n = 6) of dabigatran (B). (C,D) Kaplan-Meier curves of mortality rate in 5/6 nephrectomy mice treated with 2.5 mg/kg/day (n = 8) and 5.0 mg/kg/day (n = 8) of warfarin (C) or with 200 mg/kg/day (n = 7) and 400 mg/kg/day (n = 6) of dabigatran (D). 5/6NE, 5/6 nephrectomy; Tx, beginning of treatment.

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  Figure 2. Serum creatinine changes and hematuria in 5/6 nephrectomy mice treated with warfarin and dabigatran. (A,B) Serum creatinine changes in 5/6 nephrectomy mice treated with 2.5 mg/kg/day (n = 8) and 5.0 mg/kg/day (n = 8) of warfarin (A) or with 200 mg/kg/day (n = 7) and 400 mg/kg/day (n = 6) of dabigatran (B). Control (vehicle-treated group) data on day 0 and 7 are shown in a solid diamond on both (A,B). (C,D) Hematuria in 5/6 nephrectomy mice treated with 2.5 mg/kg/day (n = 8) and 5.0 mg/kg/day (n = 8) of warfarin (C) or with 200 mg/kg/day (n = 7) and 400 mg/kg/day (n = 6) of dabigatran (D). 5/6NE, 5/6 nephrectomy; Tx, beginning of treatment. *p < 0.05 as compared to day 0 of treatment. Hematuria was quantitated by a semiquantitative scale from 0 to 3, where 0 is absent, 1 is mild, 2 is moderate, and 3 is severe.