Key result
Partial constriction of the abdominal aorta in rabbits increased arterial pressure, which correlated with the time course of vascular smooth muscle cell proliferation.
Why the study?
Does partial constriction of the abdominal aorta induce cellular proliferation in rabbit arteries correlated with increased arterial pressure?
Does partial constriction of the abdominal aorta induce cellular proliferation in rabbit arteries correlated with increased arterial pressure?
In a rabbit model, hypertension induced by aortic constriction correlates temporally with vascular smooth muscle cell proliferation in the arterial wall.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for pressure-induced vascular remodeling in rabbits; leaves open relevance to human hypertensive disease.
Following partial constriction of the abdominal aorta, and the increase in arterial pressure in vessels proximal to the ligature at 3, 6, 14, 21, and 28 days was correlated with pathological changes and with proliferation of cells in the arterial wall measured by 3H-thymidine labeling indices and mitotic counts. The time course of arterial pressure rise and vascular smooth muscle cell proliferation were similar. Patterns of proliferation of cells of the artery wall varied in distribution with time, the presence of absence of traumatic changes seen by light microscopy, and the histological structure of the vessel. Arteries not subject to hypertension did not differ from sham-operated animals.
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Rosemary D. Bevan (2008) studied Hypertension. Partial constriction of the abdominal aorta vs. Sham operation was evaluated on Proliferation of cells in the arterial wall and pathological changes. Partial constriction of the abdominal aorta in rabbits increased arterial pressure, which correlated with the time course of vascular smooth muscle cell proliferation.
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