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June 1, 1985Journal of Hypertension

Regional Circulations in Experimental Coarctation of the Aorta in Conscious Dogs

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Why the study?

Does experimental coarctation of the aorta alter regional blood flows and vascular resistance in conscious dogs?

Population

35 conscious dogs

Comparison

Creation of a stenosis of the descending… vs Sham-operated control group

Design

Preclinical

Follow-up

up to 28 days

Authors

JLJean-François LiardMedical College of WisconsinJSJean-Claude SpadoneUniversity of Fribourg

Discussion

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Implication

No immediate clinical implications in coarctation; hypothesis-generating for systemic vasoconstrictor mechanisms requiring human validation.

Structured PICO

Does experimental coarctation of the aorta alter regional blood flows and vascular resistance in conscious dogs?

P
Population
35 conscious dogs
I
Intervention
Creation of a stenosis of the descending thoracic aorta (experimental coarctation)
C
Comparator
Sham-operated control group
O
Outcome
Regional blood flows and vascular conductance measured with radioactive microspheressurrogate

Experimental aortic coarctation in dogs induces a late generalized increase in vascular resistance even in tissues not exposed to increased arterial pressure, suggesting a systemic vasoconstrictor mechanism.

Cite This Study

Liard et al. (1985) studied this question.

synapsesocial.com/papers/6a94d994b1b9682fb47c408fhttps://doi.org/10.1097/00004872-198506000-00014

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left ventricular responses to experimental aortic coarctation in growing puppies1991 · 3 citations
  2. 2Effects of systemic hypertension on ischemic and nonischemic regional left ventricular function in awake, unsedated dogs after experimental coronary occlusion.1982 · 22 citations
  3. 3Temporal evolution of mechanical stimuli from vascular remodeling in response to the severity and duration of aortic coarctation in a preclinical model2023 · 16 citations
  4. 4Temporal evolution of mechanical stimuli from vascular remodeling in response to the severity and duration of aortic coarctation2022
  5. 5Day-to-Day Changes in Coronary Hemodynamics Secondary to Constriction of Circumflex Branch of Left Coronary Artery in Conscious Dogs1968 · 98 citations