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February 1, 1989British Journal of Clinical PharmacologyOpen Access

The pharmacokinetics of lisinopril in hospitalized patients with congestive heart failure.

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Why the study?

What are the pharmacokinetics of oral versus intravenous lisinopril in hospitalized patients with congestive heart failure?

Population

12 in-patients with stable, chronic congestive heart failure (CHF)

Comparison

Lisinopril administered orally and intravenously… vs Intravenous vs oral administration (crossover)

Design

RCT, randomized, balanced, two-period, crossover design, open

Follow-up

72 hours per dose period

Authors

ATA. E. TillUnited States Military AcademyKDKenneth DicksteinHeart Failure & TransplantTATorbjørn AarslandStavanger University Hospital

Discussion

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Implication

Alerts to potential under-exposure with oral lisinopril in heart failure; extends pharmacokinetic data to this population.

Structured PICO

What are the pharmacokinetics of oral versus intravenous lisinopril in hospitalized patients with congestive heart failure?

P
Population
12 in-patients with stable, chronic congestive heart failure (CHF)
I
Intervention
Lisinopril administered orally (10 mg) and intravenously (5 mg) in a two-period crossover design
C
Comparator
Intravenous vs oral administration (crossover)
O
Outcome
Pharmacokinetics of lisinopril (urinary recovery, absorption/bioavailability, serum concentrations)surrogate

Lisinopril exhibits reduced absorption and altered disposition in patients with congestive heart failure, suggesting disease state and age may affect its pharmacokinetics.

Cite This Study

Till et al. (1989) studied this question.

synapsesocial.com/papers/6a8c3cd39d5fb440a3becf9fhttps://doi.org/10.1111/j.1365-2125.1989.tb05351.x

Topics

Heart failureHFrEF treatmentHeart failure hospitalization
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hemodynamic, Hormonal, and Pharmacokinetic Aspects of Treatment with Lisinopril in Congestive Heart Failure1987 · 22 citations
  2. 2Lisinopril pharmacokinetics in chronic renal failure.1988 · 17 citations
  3. 3Placebo-Controlled Study of Lisinopril in Congestive Heart Failure1987 · 90 citations
  4. 4Hormonal and renal differences between low dose and high dose angiotensin converting enzyme inhibitor treatment in patients with chronic heart failure.1996 · 47 citations
  5. 5Comparison of the pharmacokinetics of fosinoprilat with enalaprilat and lisinopril in patients with congestive heart failure and chronic renal insufficiency2000 · 46 citations