Why the study?
Does fosinopril exhibit less pharmacokinetic accumulation than enalapril or lisinopril in patients with congestive heart failure and chronic renal insufficiency?
Population
55 patients with congestive heart failure and chronic renal insufficiency
Comparison
Fosinopril 10 mg every morning for 10… vs Enalapril 2.5 mg or lisinopril 5 mg every…
Design
RCT, Randomized to receive fosinopril, enalapril or lisinopril in two…
Follow-up
10 days
Authors
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Supports preferring fosinopril in HF with renal insufficiency to minimize accumulation; extends RCT evidence of its pharmacokinetic advantage versus enalapril or lisinopril.
Does fosinopril exhibit less pharmacokinetic accumulation than enalapril or lisinopril in patients with congestive heart failure and chronic renal insufficiency?
Fosinopril exhibits significantly less accumulation than enalapril or lisinopril in patients with heart failure and severe renal insufficiency, likely due to its dual hepatic and renal elimination pathways.
Greenbaum et al. (2000) studied this question.
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