April 1, 1991Clinical Pharmacology & Therapeutics

Pharmacokinetics of fosinopril in patients with various degrees of renal function

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Why the study?

How does the degree of renal impairment affect the pharmacokinetics and clearance of single-dose fosinopril?

Population

Patients with mild, moderate, or severe renal impairment and patients with normal renal function.

Comparison

Single-dose intravenous 14C-fosinoprilat and… vs Patients with normal renal function compared to…

Design

Other

Authors

KHKa Kit HuiWest Los Angeles College KDKenneth L. DuchinRutgers, The State University of New Jersey KKK. J. KripalaniBristol-Myers Squibb (Germany)

Discussion

Member takes

Implication

Supports fosinopril dosing independent of renal impairment severity; leaves open need for larger PK validation studies.

Structured PICO

How does the degree of renal impairment affect the pharmacokinetics and clearance of single-dose fosinopril?

Population

Patients with mild, moderate, or severe renal impairment (creatinine clearance values of 11 to 72 ml/min/1.73 m2) and patients with normal renal function.

Intervention

Single-dose intravenous 14C-fosinoprilat (7.5 mg) and oral 14C-fosinopril (10 mg).

Comparator

Patients with normal renal function compared to those with varying degrees of renal impairment.

Outcome

Pharmacokinetics, including total body clearance, plasma kinetics, and bioavailability.surrogate

Fosinopril exhibits dual elimination by the liver and kidney, allowing total clearance to be maintained across varying degrees of renal impairment.

Cite This Study

Hui et al. (1991) studied this question.

synapsesocial.com/papers/6a765f23e4645e92c9bd2793 https://doi.org/10.1038/clpt.1991.54

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