Why the study?
Does fosinopril improve blood pressure control compared to hydrochlorothiazide in patients with mild to moderate hypertension?
Population
17 patients with mild to moderate hypertension (diastolic blood pressure of 95-115 mmHg, WHO I)
Comparison
Fosinopril 5 mg orally once daily for 4 weeks… vs Hydrochlorothiazide 25 mg orally once daily for…
Design
RCT, randomized, parallel study, double-blind
Follow-up
8 weeks
Authors
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Hydrochlorothiazide achieves superior systolic control versus fosinopril; reinforces thiazide preference over ACE-inhibitor monotherapy for systolic hypertension.
Does fosinopril improve blood pressure control compared to hydrochlorothiazide in patients with mild to moderate hypertension?
Fosinopril is a safe antihypertensive that lowers diastolic blood pressure similarly to hydrochlorothiazide, though hydrochlorothiazide provides better systolic blood pressure control but with adverse metabolic effects.
Forslund et al. (1991) studied this question.
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