Why the study?
Beyond vaccine failure from strain mismatch, producing inactivated FMD vaccines carries danger if adequate biosafety cannot be maintained.
High-throughput sequencing revealed that a local inactivated FMD vaccine contained a strain genetically identical to recent outbreak viruses, suggesting accidental release of virulent virus.
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Warrants urgent biosafety review of FMD vaccines; leaves open causal role in outbreaks pending further evidence.
In addition to the risk of vaccine failure caused by strain mismatch, the production of inactivated FMD vaccines is dangerous if adequate biosafety cannot be maintained. Using a high-throughput sequencing protocol optimized for short nucleic acid fragments, the composition of a local inactivated vaccine was analyzed in depth. The serotype O strain identified in the vaccine was genetically identical to viruses found in recent FMD outbreaks in Egypt.
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Rahman et al. (2020) studied this question.
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