Why the study?
Do laboratory assays for heparin monitoring correlate with clinical outcomes in high-risk patients receiving low molecular weight versus unfractionated heparin prophylaxis?
Population
High-risk patients (likely surgical) receiving heparin prophylaxis
Comparison
Low molecular weight heparin prophylaxis vs Unfractionated heparin prophylaxis
Design
Cohort
Loading...
Standard assays should not guide heparin prophylaxis dosing; hypothesis-generating for protein C, AT III, and PAI levels as DVT predictors.
Do laboratory assays for heparin monitoring correlate with clinical outcomes in high-risk patients receiving low molecular weight versus unfractionated heparin prophylaxis?
Standard laboratory assays for heparin monitoring do not reliably predict clinical outcomes or dosing needs in high-risk patients, though specific markers like protein C, AT III, and PAI levels correlate with DVT risk.
A 1993 study studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: