Inhibition of the automaticity of the Limulus heart ganglion by inhibitory nerves is mediated by a decrease in CO2-producing chemical reactions rather than a simple blocking process.
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Indicates metabolic mediation of inhibition in Limulus ganglion; leaves open applicability to mammalian cardiac automaticity.
It has been shown in this paper that stimulation of the inhibitory nerves of the neurogenic heart of Limulus, which correspond to the vagus nerves of the vertebrate heart, results in a marked diminution of CO(2) production in the heart ganglion, while stimulation of the ganglion, leading to increased activity of the heart, leads also to increased CO(2) production by the ganglion. This shows that inhibition of the automaticity of this ganglion by the action of its inhibitory nerves consists, not in a process of blocking, but in a diminution of those chemical reactions in the ganglion cells which give rise to the production of CO(2).
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Walter E. Garrey (1920) studied this question.
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