Population
Spontaneously hypertensive rat (SHR) aorta
Comparison
Decreasing extracellular pH from 7.4 to 6.5… vs Normal extracellular pH or absence of inhibitors
Design
Preclinical
Authors
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Acidic pH contracts SHR aorta via Ca2+ pathways; hypothesis-generating in animal models and leaves open human hypertension relevance.
Acidic pH induces contraction in spontaneously hypertensive rat aorta through both Ca2+ release from the sarcoplasmic reticulum and Ca2+ influx via voltage-dependent calcium channels.
Rohra et al. (2003) studied this question.
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