Population
Rabbit renal cortex and isolated proximal tubules
Comparison
Dexamethasone (chronic administration 600… vs Untreated controls / baseline
Design
Preclinical
Follow-up
Up to 2 days
Authors
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Dexamethasone exerts time-dependent effects on renal Na/H exchange in animals; leaves open clinical translation to glucocorticoid therapy.
Chronic dexamethasone increases NHE-3 mRNA abundance, whereas acute dexamethasone increases Na+/H+ antiporter activity via mechanisms independent of NHE-1 and NHE-3 mRNA changes.
Baum et al. (1994) studied this question.
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